Multivariate classification of gene expression microarray data

L'expressiódels gens obtinguts de l'anàliside microarrays s'utilitza en molts casos, per classificar les cèllules. En aquestatesi, unaversióprobabilística del mètodeDiscriminant Partial Least Squares (p-DPLS)s'utilitza per classificar les mostres de les expressions delsseus gens. p-DPLS esbasa en la regla de Bayes de la probabilitat a posteriori. Aquestsclassificadorssónforaçats a classficarsempre.Per superaraquestalimitaciós'haimplementatl'opció de rebuig.Aquestaopciópermetrebutjarlesmostresamb alt riscd'errors de classificació (és a dir, mostresambigüesi outliers).Aquestaopció de rebuigcombinacriterisbasats en els residuals x, el leverage ielsvalorspredits. A més,esdesenvolupa un mètode de selecció de variables per triarels gens mésrellevants, jaque la majoriadels gens analitzatsamb un microarraysónirrellevants per al propòsit particular de classificacióI podenconfondre el classificador. Finalment, el DPLSs'estenen a la classificació multi-classemitjançant la combinació de PLS ambl'anàlisidiscriminant lineal

Editorial: Positive Technology: Designing E-experiences for Positive Change

While there is little doubt that our lives are becoming increasingly digital, whether this change is for the better or for the worse is far from being settled. Rather, over the past years concerns about the personal and social impacts of technologies have been growing, fueled by dystopian Orwellian scenarios that almost on daily basis are generously dispensed by major Western media outlets. According to a recent poll involving some 1,150 experts, 47% of respondents predict that individuals’ well-being will bemore helped than harmed by digital life in the next decade, while 32% say people’s well-being will bemore harmed than helped. Only 21% of those surveyed indicated that the impact of technologies on people well-being will be negligible compared to now (Pew Research Center, 2018)

Los tratamientos psicológicos basados en la evidencia

Lliçó inaugural del curs 2009-2010

Users’ Opinion About a Virtual Reality System as an Adjunct to Psychological Treatment for Stress-Related Disorders: A Quantitative and Qualitative Mixed-Methods Study

This study aims to explore patients’ and therapists’ attitudes about the psychological treatment they received (patients) or applied (therapists). The treatments were standard CBT protocols for post-traumatic stress disorder (PTSD), complicated grief (CG), or adjustment disorders (ADs), depending on each patient diagnosis. The treatments were delivered following a traditional format or supported by a virtual reality (VR) system “EMMA’s WORLD” designed for the treatment of stress-related disorders. “EMMA’s WORLD” is a VR application in which patients can explore negative experiences using different virtual elements that can be customized to make them more meaningful to the user. The sample was composed of two groups: the “professionals” ( N = 10) were all clinical psychologists who applied the same psychological treatment in both the traditional format (“traditional condition”) and using the VR system (“ EMMA” condition). The second group consisted of a sample of patients ( N = 50) who met the criteria for at least one of three different diagnoses: PTSD ( N = 15), CG ( N = 15), or AD ( N = 20). 25 patients received treatment in the traditional format and 25 supported by the VR system. The patients were asked about their expectations (before treatment) and satisfaction (after treatment) with the treatment they received. All the therapists were asked their opinions about both treatment conditions. A mixed-methods approach using quantitative and qualitative methodologies was used. In both conditions, high scores were observed, and the patient’s opinions were even better when they have already received the treatments. A more pronounced pre-test–post-test change in the EMMA therapy group than in the traditional group was observed. EMMA’s World was well- accepted by both patients and therapists, and it helped to foster motivation in patients, while helping the therapist to apply the treatment. Thus, VR can be useful as an adjunct tool to enhance the treatmen

Detection and distraction effects for threatening information in social phobia and change after treatment

This work examines differences in the detection and distraction by social-threatrelated information between a social phobia group (SP; N533) and a normal control group (NC; N532). The change obtained after psychological treatment is also studied for the SP group. A paper-and-pencil visual search task is used, in which the emotional valence of the ‘‘target’’ (social threat, physical threat, and neutral words) and ‘‘distractor’’ (social threat, physical threat, neutral, and nonsense words) verbal stimuli is manipulated. Results indicate that there are no differences in the detection of social-threat targets between SP and NC participants. However, the performance of SP individuals is more impaired when distractor stimuli related to social threat are presented, regardless of the target valence. This increased distraction by social-threat-related stimuli is reduced after psychological treatment, and this decrease is maintained at 6-month follow-u

Upregulating Positive Affectivity in the Transdiagnostic Treatment of Emotional Disorders: A Randomized Pilot Study

Transdiagnostic cognitive-behavioral therapy for emotional disorders (ED) has proven to be effective. However, current transdiagnostic treatment protocols address only the regulation of negative affectivity, and they do not include treatment components to more directly target the regulation of positive affectivity. In this study, we propose to evaluate the preliminary efficacy and acceptability of a transdiagnostic treatment protocol for ED that includes, as an innovative feature, a specific treatment component to directly upregulate positive affectivity based on positive psychology interventions. A total of 24 participants were randomized to either a transdiagnostic treatment protocol (n = 12) or a transdiagnostic treatment protocol with an additional component designed to regulate positive affectivity (n = 12). Participants completed measures of anxiety, depression, positive and negative affectivity, and quality of life, as well as treatment acceptability at pre- and posttreatment and at the 3-month follow-up. Both interventions led to improvements in all measures at posttreatment, and these outcomes were maintained at the 3-month follow-up, with large effect sizes for all measures. The effect sizes for positive affect were larger in the condition that included the component to upregulate positive affectivity. Attrition rate was low, and both treatment protocols were well accepted by participants. The results obtained in this study indicate the feasibility of testing the treatment protocol in a larger, randomized, controlled trial, and they suggest the potential of including treatment components for directly upregulating positive affectivity in future research on transdiagnostic treatment protocols for ED

Internet-Based Self-Help Program for the Treatment of Fear of Public Speaking: A Case Study.

This article discusses the development of the first totally self-administered online CBT program for the treatment of a specific social phobia (fear of public speaking) called talk to me. The online program includes three parts. The assessment protocol gives the patient information about the problem, including impairment, severity, and the degree of fear and avoidance regarding the main feared situations. The structured treatment protocol ensures that the patient does not skip any steps in the treatment. The treatment protocol is a CBT program that provides exposure to the feared situation using videos of real audiences. Finally, the control protocol assesses treatment efficacy, not only at posttreatment, but also at every intermediate step. In this work we describe talk to Me and its practical application through a case study

Virtual reality and stimulation of touch and smell for inducing relaxation: A randomized controlled trial

The aim of this study was to test the efficacy of a mood-induction procedure in a Virtual Reality (VR-MIP) environment for inducing relaxation and generating sense of presence, and to test whether the stimulation of the senses of touch and smell improves the efficacy of this VR-MIP. A controlled study was carried out with four experimental conditions. All of them included the VR-MIP to induce relaxation, but varying the senses stimulated. The sample consisted of 136 participants randomly assigned to one of the four experimental conditions. Emotions and sense of presence were evaluated. The results showed statistical differences before and after mood-induction and a high sense of presence in all groups. However, no statistical differences were found among the four groups on emotions and sense of presence. The results showed that the VR-MIP was effective; however, the stimulation of the senses of touch and smell did not show significate improve of the mood-induction or the sense of presence. It was identified a trend in favor of the groups where the sense of touch was stimulated, they seemed more relaxed and the sense of presence was higher. We hypothesized that the stimulation of sense of touch, could improve the efficacy when using VR-MIP because it provides more sensory information.This work was funded by the 4Senses project (PSE-020400-2007-1) and the Consolider project (SEJ2006-14301/PSIC) of the Ministry of Science and Innovation in Spain (Ministerio de Ciencia e Innovación de España)

The buffer role of meaning in life in hopelessness in women with borderline personality disorders

Meaning in life has been found to be a protective factor against suicidal ideation. The aim of this study was to investigate whether meaning in life can moderate and buffer the association between suicide risk factors and hopelessness in women with borderline personality disorders. One hundred twenty-four women diagnosed with borderline personality disorder completed self-report measures of suicide risk factors, hopelessness, and meaning in life. The main result from this study was that meaning in life moderated the association between suicide risk factors and hopelessness. Meaning in life is an important variable in the prevention and treatment of risk of suicide in women with borderline personality disorder